Further study on the possibilities of using the selective zygote enucleation method in mammalian cloning. Analysis of cell reprogramming in somatic-chimeric chimeras during pre-implantation, post-implantation and postnatal development. Improve the cryopreservation of oocytes based on the study of biological mechanisms of cell responses to stimuli generated by these procedures. Research on control of in vitro maturation of oocytes. Study on the sheep model, the effect of n-3 PUFA enriched diet on maternal immune activation and on Autistic Spectrum Disorders (ASD) Understanding the mechanisms of embryonic development, in particular the demand for rabbit embryos in pre-implantation development on various energy substrates, and the development of a breeding system providing the most physiological development conditions. To investigate whether biopsy of blastomers interferes with embryonic development and is therefore a favorable factor for the emergence of acquired offspring, upon maturation, of the metabolic syndrome (MS). Understanding the genetic and epigenetic mechanisms of apoptosis regulation (programmed cell death) in pre-implantable mouse embryos. Research on molecular mechanisms of differentiation of extra-embryonic lines - thymidine and endoderm - in pre-implant rabbit embryos.