Paweł Leszczyński PhD

Position: Research assistant at the Institute of Genetics and Animal Biotechnology PAS. Laboratory for Genome Editing and Transcriptional Regulation

Field of interest:Neurobiology, Epigenetics, Cancer Molecular Biology.

Scientific achievements:11 publications including a chapters in books.

Realized research projects:PRELUDIUM 13 (NCN): ,,Epigenetic role of Prdm3 protein during neurogenesis”, Principal Investigator.

Selected publications:

Leszczynski P, Śmiech M, Teeli AS, Haque E, Viger R, Ogawa H, Pierzchała M,  Taniguchi H. “Deletion of the Prdm3 gene causes a neuronal differentiation deficiency in P19 cells”. International Journal of Molecular Sciences 2020, in press.

Haque E, Karim MR, Teeli AS, Śmiech M, Leszczynski P, Winiarczyk D, Parvanov ED, Atanasov AG, Taniguchi H. ,, Molecular Mechanisms Underlying Hepatocellular Carcinoma Induction by Aberrant NRF2 Activation-Mediated Transcription Networks: Interaction of NRF2-KEAP1 Controls the Fate of Hepatocarcinogenesis”. International Journal of Molecular Sciences 2020; 21 (15), 5378; 1-19.

Śmiech M, Leszczyński P, Haque E, Taniguchi H. ,,Cloning-Free (DNA-Free) CRISPR-Cas9-Mediated Gene Editing in Human Liver Cell Line and Its Detection”. CRISPR-Cas Methods 2020; 163-171.

Teeli AS, Leszczyński P, Krishnaswamy N, Ogawa H, Tsuchiya M, Śmiech M, Skarzynski D, Taniguchi H. ,,Possible Mechanisms for Maintenance and Regression of Corpus Luteum Through the Ubiquitin-Proteasome and Autophagy System Regulated by Transcriptional Factors”. Frontiers in Endocrinology 2019; vol.10:748.

Yamazaki T, Kishimoto T, Leszczyński P, Sadakane K, Kenmotsu T, Watanabe H, Kazama T, Matsumoto T, Yoshikawa K, Taniguchi H. “Construction of 3D Cellular Composites with Stem Cells Derived from Adipose Tissue and Endothelial Cells by Use of Optical Tweezers in a Natural Polymer Solution”. Materials (Basel) 2019;12(11):1759

Leszczyński P, Śmiech M, Teeli AS, Zołocińska A, Słysz A, Pojda Z, Pierzchała M, Taniguchi H. ,,Neurogenesis Using P19 Embryonal Carcinoma Cells”. Journal of Visualized Experiments 2019; 146, e58225.

Lesniak A, Leszczynski P, Bujalska-Zadrozny M, Pick CG, Sacharczuk M. “Naloxone exacerbates memory impairments and depressive-like behavior after mild traumatic brain injury (mTBI) in mice with upregulated opioid system activity”. Behavioural Brain Research 2017;326:209-216

Suska M, Lewicki S, Kiepura A, Winnicka I, Leszczyński P, Bielawska-Drózd A, Cieślik P, Kubiak L, Depczyńska D, Brewczyńska A, Skopińska-Różewska E, Kocik J. “Pollution of mycological surfaces in hospital emergency departments correlates positively with blood NKT CD3(+) 16(+) 56(+) and negatively with CD4(+) cell levels of their staff”. Central European Journal of Immunology 2016;41(1):71-77.

Lewicki S, Bielawska-Drózd A, Winnicka I, Leszczyński P, Cieślik P, Korniłłowicz-Kowalska T, Bohacz J, Jaroszuk-Ściseł J, Skopińska-Różewska E, Kocik J. “Negative correlation between mycological surfaces pollution in hospital emergency departments and blood monocytes phagocytosis of healthcare workers”. Central European Journal of Immunology 2015;40(3):360-365.

Leszczyński P, Lewicka A, Suska M, Rzeski W. Book chapter. „Właściwości produktów pochodzenia naturalnego w chemoprewencji nowotworów”. Wybrane zagadnienia biologii i medycyny. 35-46 pages. Collective work edited by Andrzej Krzysztof Siwicki, Ewa Skopińska – Różewska, Robert Zdanowski, Edition ISBN 978-83-94917-1-9, 2015.
 

Link to professional profile: https://www.scopus.com/authid/detail.uri?authorId=57191829800